131 articles - From Friday Jan 05 2024 to Friday Jan 12 2024
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Am J Gastroenterol |
|---|
ACG Clinical Guideline: Alcohol-Associated Liver Disease. Level of evidence and strength of recommendations were evaluated using the Grading of Recommendations, Assessment, Development, and Evaluations system. This guideline was developed under the American College of Gastroenterology Practice Parameters Committee. |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
|---|
Systematic review and meta-analysis: Risk of gastric cancer in patients with first-degree relatives with gastric cancer. This meta-analysis highlights the relevance of patients' family history of gastric cancer and the importance of this risk factor for the early detection of neoplastic conditions. |
Systematic review with meta-analysis: Cause-specific and all-cause mortality trends across different coeliac disease phenotypes. Mortality in coeliac disease is increased, predominantly due to malignancies-particularly non-Hodgkin lymphoma-although differing significantly across disease phenotypes. Mortality of patients with coeliac disease has significantly decreased in recent decades. These results may influence diagnosis and management. |
Systematic review with meta-analysis: Steatosis severity and subclinical atherosclerosis in metabolic dysfunction-associated steatotic liver disease. Even mild steatosis is associated with CVD risk, and steatosis severity further intensifies this association. These findings suggest that liver fat quantification enhances CVD risk stratification in patients with MASLD. |
Systematic review: Clinical phenotypes, histopathological features and prognosis of enteropathy due to angiotensin II receptor blockers. Enteropathy due to ARBs is characterised by severe malabsorption often requiring hospital admission and can involve the entire gastrointestinal tract. Clinician awareness can lead to prompt diagnosis and excellent prognosis. |
| Clin Gastroenterol Hepatol |
Comparative Efficacy of Advanced Therapies for Achieving Endoscopic Outcomes in Crohn's Disease: A Systematic Review and Network Meta-Analysis. On network meta-analysis, JAK1 inhibitors and anti-IL23p19 agents may be the most effective amongst non-TNF-targeting advanced therapies for inducing endoscopic response. Future head-to-head trials will further inform positioning of different therapies for the management of CD. |
| Endosc Int Open |
Intraductal radiofrequency ablation plus biliary stent versus stent alone for malignant biliary obstruction: a systematic review and meta-analysis. RFA+S improved OS in the treatment of MBO when compared with S-alone. Moreover, the RFA therapy prolonged stent patency in hilar strictures and CCA, with similar rates of AEs. |
| Gastroenterology |
Accuracy of the no-biopsy approach for the diagnosis of coeliac disease in adults: a systematic review and meta-analysis. Only one study had a low risk of bias across al domains. The results of this meta-analysis suggest that selected adult patients with IgA-tTG =10×ULN and a moderate to high pre-test probability of coeliac disease could be diagnosed without undergoing invasive endoscopy and duodenal biopsy. |
| Gastrointest Endosc |
Efficacy of Artificial Intelligence in Reducing Miss Rates of Gastrointestinal Adenomas, Polyps, and Sessile Serrated Lesions: A Meta-analysis of Randomized Controlled Trials. This meta-analysis suggested that AI technology led to significant reduction of miss rates for GI adenomas, polyps, and sessile serrated lesions (SSL) during endoscopy surveillance. These results underscore the potential of AI to improve the accuracy and efficiency of GI endoscopy procedures. |
| J Neurogastroenterol Motil |
Symptomatic Response to Antibiotics in Patients With Small Intestinal Bacterial Overgrowth: A Systematic Review and Meta-analysis. Antibiotics appear to be efficacious in treating SIBO, although small sample sizes and poor data quality limit this interpretation. Symptomatic response rates also appear to be higher in IBS patients with SIBO. This may be the first example of precision medicine in IBS as opposed to our current empiric treatment approach. Large-multicenter studies are needed to verify the results. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
Comparison of 1-day versus 3-day intravenous terlipressin in cirrhosis patients with variceal bleeding: A pilot randomised controlled trial. Our results suggest that 1 day of terlipressin therapy is associated with similar 5-day and 42-day rebleeding rates, 42-day mortality and an overall superior safety profile compared with 3-day of terlipressin therapy. These findings require to be validated in double-blinded, larger, multiethnic and multicentre studies across the various stages of cirrhosis (CTRI/2019/10/021771). |
Determining optimal ALT cut-off values for predicting significant hepatic histological changes in patients with normal ALT in the grey zone of chronic hepatitis B virus infection. This study established novel optimal ALT cut-off values for more precise prediction of SLHC among Chinese patients with GZ CHB and normal ALT levels. This may help identify individuals who will benefit from timely antiviral therapy. |
Duke Activity Status Index and Liver Frailty Index predict mortality in ambulatory patients with advanced chronic liver disease: A prospective, observational study. Poor functional exercise capacity and physical frailty are highly prevalent among ambulatory patients with CLD who are being assessed for LT. The DASI and LFI are simple, low-cost tools that predict overall and pre-LT mortality. Implementation of both should be considered in al outpatients with CLD to highlight those who may benefit from targeted nutritional and exercise interventions. |
Racial and ethnic disparities in untreated patients with hepatitis C virus-related hepatocellular carcinoma but not in those with sustained virologic response. DAA treatment rates were suboptimal. Racial and ethnic disparities resolved with HCV cure. Early diagnosis and improved access to HCV treatment is needed for al patients with HCV infection. |
| Am J Gastroenterol |
NATURAL HISTORIES AND DISEASE COMPLICATIONS IN A COHORT OF 151 CHILDREN WITH GASTRIC OR DUODENAL EOSINOPHILIA. Patients with gastric and duodenal eosinophilia should be followed closely to monitor for recurrence and complications, especially those presenting with endoscopic abnormalities or complications. |
| Clin Gastroenterol Hepatol |
Randomized trial of patient outreach approaches to de-implement outdated colonoscopy surveillance intervals. Also, more patients adopted the 10-year surveillance interval in the telephone (37.0%) and secure messaging arms (32.0%) compared to mailed letter (18.9%) and rate differences were significant for telephone (18.1%; 97.5% CI: 8.3%, 27.9%) and secure message outreach (13.1%; 97.5% CI: 3.5%, 22.7%) versus mailed letter outreach. Telephone and secure messaging were more effective than mailed letter outreach for de-implementing outdated colonoscopy surveillance recommendations among individuals with a history of low-risk adenomas in an integrated healthcare setting. |
Reduction of upper gastrointestinal bleeding risk with proton pump inhibitor therapy in Asian patients with atrial fibrillation receiving direct oral anticoagulant: A nationwide population-based cohort study. In this large Asian cohort of patients with AF on DOAC, PPI co-therapy is beneficial for reducing the risk of hospitalization for UGIB, particularly in high-risk patients. |
Type 1 Autoimmune Pancreatitis in Europe: Clinical Profile and Response to Treatment. Patients with type 1 AIP and elevated IgG4 level may need closer monitoring. For remission induction, a starting dose of 0.4 mg/kg/day for 2 weeks followed by a short taper period seems effective. This study provides no evidence to support more aggressive regimens. |
| Endosc Int Open |
Incidence of persistent SARS-CoV-2 gut infection in patients with a history of COVID-19: Insights from endoscopic examination. Smokers and individuals with diabetes may be at an increased risk of persistent viral gut infection. These findings provide insights into the dynamics of SARS-CoV-2 infection in the gut and have implications for further research. |
Is a higher frequency of esophageal dilations more effective in treating benign esophageal strictures? Retrospective, multicenter study. The results of our study demonstrate that a treatment concept consisting of higher-frequency bougienages seems to be more effective in treating most types of esophageal stricture. Radiogenic strictures were the only types of stenoses that benefited from a lower frequency ED program. |
Prevention of peri-interventional hypothermia during endoscopic retrograde cholangiopancreatography using a forced-air heating system. Hypothermia occurred in the majority of patients undergoing prolonged endoscopic sedation without active temperature control. FAHS was associated with higher temperature stability during sedation and better patient comfort. |
Provider-reported use of butylscopolamine in gastrointestinal endoscopy in Germany. German-speaking endoscopists commonly use HBB, most frequently to facilitate complex therapeutic procedures. Given there is almost no data supporting HBB use in therapeutic endoscopy, we suggest that more research is needed to evaluate benefits and risks of this practice. |
Safety and efficacy of physician-administered balanced-sedation for the endoscopic mucosal resection of large non-pedunculated colorectal polyps. Physician-administered balanced sedation for the EMR of LNPCPs is safe. Peri-procedural AEs are infrequent, transient, rarely require admission (<1%), and are experienced in similar frequencies to those receiving anesthetist-managed sedation. |
Through-the-scope clip retention rates and performance in a porcine model. All clips were equivalent in efficacy and safety with successful clip deployment and mucosal healing. Overall retention rate was low for fibrotic tissue, with an improved retention rate observed with Resolution clips. |
Transoral incisionless fundoplication with or without hiatal hernia repair for gastroesophageal reflux disease after peroral endoscopic myotomy. TIF and cTIF for difficult-to-control post-POEM GERD appear safe, decrease PPI use and reflux episodes, and improve QOL without significant change in IRP, EGJ compliance, diameter or esophageal acid exposure time. |
| Endoscopy |
Artificial intelligence-assisted linked color imaging versus linked color imaging for colorectal adenoma detection: the first randomized controlled trial. In both the groups, there was no significant difference in the ADR between experts and trainees. LCA is significantly superior to LC in terms of the ADR. |
E-learning accelerates improvement of endoscopists' proximal serrated polyp detection rate: a randomized controlled trial. In an era of increased awareness and increasing PSPDRs, endoscopists who performed an one-time e-learning significantly accelerated the increase of PSPDR compared to endoscopists who did not receive the e-learning. Widespread implementation might reduce PCCRCs incidence. This trial was registered with the Netherlands Trial Register, number NL8385. |
When less is more: Lower esophageal sphincter preserving per oral endoscopy myotomy (LES-POEM) is effective for non-achalasia esophageal motility disorders (NAEMD). Two patients (11.1%) developed Los Angeles (LA) grade A or B esophagitis. LES-POEM for NAEMD demonstrates favourable clinical outcomes, with infrequent esophagitis and rare reintervention for LES dysfunction. |
| Gastroenterology |
Global prevalence of Helicobacter pylori infection and incidence of gastric cancer between 1980 and 2022. The results raised the hypothesis that public health drive to reduce the prevalence of H. pylori as a strategy to reduce the incidence of gastric cancer in the population, which should be confirmed in large scale clinical trials. |
| Gastrointest Endosc |
Automated artificial intelligence-based phase recognition system for esophageal endoscopic submucosal dissection (with video). We demonstrated that an AI-based automated phase recognition system for esophageal ESD can be established with high accuracy. To the best of our knowledge, this is the first report on automated recognition of ESD treatment phases. Since this system enabled a detailed analysis of phases, collecting large volumes of data in the future may help identify quality indicators for treatment techniques and uncover unmet medical needs that necessitate the creation of new treatment methods and devices. |
Clinical Usefulness of Hypoxia Imaging Colonoscopy for the Objective Measurement of Ulcerative Colitis Disease Activity. Methods This was a retrospective cohort study comprised of 100 consecutive UC patients who underwent hypoxia imaging colonoscopy between September 2022 and September 2023 at the University of Tsukuba Hospital. We measured colonic tissue oxygen saturation (StO may be a novel and objective endoscopic measurement. |
Differences between men and women with respect to colorectal cancer mortality despite screening colonoscopy. Our findings strengthen the necessity of sex specific screening recommendations. Importantly, further prospective studies should focus on sex difference in tumor biology to propose personalized surveillance guidelines. |
Efficacy and safety of MC-003 solution for endoscopic mucosal or submucosal resection: A prospective, multicenter, randomized, triple-blinded, parallel-group, phase 3 study. MC-003 outperformed NS in reducing the need for additional injections during en bloc resection, particularly in larger lesions located in the distal part (where most lesions were found) during ESD procedures, without increasing the incidence of serious adverse events. MC-003 is a promising submucosal injectable solution in real-world clinical settings. |
Peroral Endoscopic Myotomy For Spastic Esophageal Dysmotility Among Opioid Users: Multicenter Propensity Score Match Study. Clinical response to POEM for SEDs and EGJOO is significantly lower among opioid users vs non-users. There was dose-relationship between opioids and response to POEM, with higher daily opioid usage associated with a higher likelihood of treatment failure. |
Valuing innovative endoscopic techniques: Hemostatic powder for the treatment of gastrointestinal tumor bleeding. These valuations should represent medical device and incremental facility costs in addition to incremental physician and staff time. Coverage for novel endoscopic hemostatic powder therapy appears cost-saving to insurers. |
| Gut |
ATP citrate lyase (ACLY)-dependent immunometabolism in mucosal T cells drives experimental colitis in vivo. ACLY controls mucosal T cell immunometabolism and experimental colitis. Therapeutic modulation of ACLY expression in T cells emerges as a novel strategy to promote the resolution of intestinal inflammation. |
Blood-based colorectal cancer screening in an integrated health system: a randomised trial of patient adherence. Among adults who had declined prior CRC screening, the offer of a blood-based screening test boosted CRC screening by 17.5 percentage points over usual care. Further research is needed on how to balance the favourable adherence with lower advanced adenoma detection compared with other available tests. |
High-fat diet promotes liver tumorigenesis via palmitoylation and activation of AKT. Our findings elucidate a novel fine-tuned regulation of AKT by PA-ZDHHC17/24-mediated palmitoylation, and highlight tumour therapeutic strategies by taking PA-restricted diets, limiting PA synthesis, or directly targeting AKT palmitoylation. |
Revisiting the performance of cyst fluid carcinoembryonic antigen as a diagnostic marker for pancreatic mucinous cysts: a comprehensive 20-year institutional review. Cyst fluid CEA continues to be a useful test in the diagnosis of mucinous pancreatic cysts but does not appear as specific as previously reported. Raising the CEA threshold to 250 ng/mL to maintain specificity for differentiating mucinous from non-mucinous cysts may be considered. |
Treatment of non-constipated irritable bowel syndrome with the histamine 1 receptor antagonist ebastine: a randomised, double-blind, placebo-controlled trial. Our study shows that ebastine is superior to placebo and should be further evaluated as novel treatment for patients with non-constipated IBS. |
Unveiling 8 years of duodenoscope contamination: insights from a retrospective analysis in a large tertiary care hospital. Duodenoscope contamination remains a significant problem, with high contamination rates despite several interventions. Reprocessing the biopsy and suction channels is especially challenging. Changes in the design of reusable duodenoscopes, such as enabling sterilisation or easily replaceable channels, are necessary to facilitate effective duodenoscope reprocessing and to eliminate the risk of duodenoscope-associated infections. |
| J Hepatol |
Ileitis promotes MASLD progression via bile acid modulation and enhanced TGR5 signaling in ileal CD8+ T cells. MASLD-induced changes in intestinal flora result in elevated levels of SBA in the ileum. In the presence of compromised intestinal barrier, this leads to severe CD8 + T cell-mediated ileitis through the TGR5/mTOR/OXPHOS signaling pathway. Ileitis-induced tissue damage impairs enterohepatic circulation, inhibits hepatic FXR activation, and exacerbates the MASLD phenotype. Impact and implications Our study provides a comprehensive investigation of the interplay and underlying mechanisms connecting ileitis and MASLD. SBA produced by intestinal bacteria, as the critical link between MASLD and ileitis. This compound exerts its influence by disrupting liver lipid metabolism through the promotion of CD8 + T cell-mediated ileitis. In future endeavors to prevent and treat MASLD, it is essential to thoroughly account for the impact of the intestinal tract, especially the ileum, on liver function via the enterohepatic circulation. |
Single-cell and spatial transcriptomics characterisation of the immunological landscape in the healthy and PSC human liver. We present a comprehensive atlas of the PSC liver and demonstrate hyper-activation and exhaustion-like phenotypes of myeloid cells and markers of chronic cytokine expression in late-stage PSC lesions. This atlas has the potential to expand our understanding of the cellular complexity of PSC and to inform novel treatment development. Impact and implications Primary sclerosing cholangitis (PSC) is a rare liver disease characterized by chronic inflammation and irreparable damage to the bile ducts resulting in liver failure. Due to a limited understanding of the underlying pathogenesis of disease, there remains a paucity of treatment options. We sequenced healthy and diseased livers to compare the activity, interactions, and localization of immune and non-immune cells. This revealed that hepatocytes lining PSC scar regions are transforming into cholangiocytes, whereas immune cells are accumulating within the scars. Of these cells, macrophages, which typically contribute to tissue repair, were enriched in immunoregulatory genes and demonstrated a lack of responsiveness to stimulation. These cells may be involved in maintaining hepatic inflammation and could be targeted in novel therapeutic drug development. |
| J Neurogastroenterol Motil |
Clinical Trial: Efficacy of Mosapride Controlled-release and Nortriptyline in Patients With Functional Dyspepsia: A Multicenter, Double-placebo, Double-blinded, Randomized Controlled, Parallel Clinical Study. Mosapride CR and nortriptyline showed similar efficacy in patients with FD regardless of the subtype. Both treatments could be equally helpful for improving quality of life and psychological well-being while also relieving dyspepsia. |
Effects of Codeine on Esophageal Peristalsis in Patients With Ineffective Esophageal Motility: Studies Using High-resolution Manometry. In IEM patients, acute administration of codeine increases contraction vigor and reduces distal latency of primary esophageal peristalsis, but has no effect on secondary peristalsis. Future studies are required to further elucidate clinical relevance of these findings, especially in the setting of gastroesophageal reflux disease with IEM. |
Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. gQlab administration can improve the overall IBS symptoms, especially in female and constipation-predominant IBS patients. Further research is necessary to clarify the pathophysiology behind sex-related treatment responses in IBS patients. |
Interpretation of Impedance Data on High-resolution Impedance Manometry Studies-A Worldwide Survey. There is no consensus on interpreting HRIM data. Providers' approaches to studies with inconsistencies between manometry and impedance data vary. There is an unmet need for guidelines on interpreting impedance data in HRIM studies. |
Relationship Between Colonic Transit Response to Eating With Self-reported Constipation Severity in Constipated Patients According to the Phenotype. Colonic transit response to eating was not associated to CS in IBS-C patients, but left CTRE was associated with constipation severity in FC and DD patients. |
The Disease Spectrum and Natural History of Patients With Abdominal Bloating or Distension: A Longitudinal Study. FGIDs are the most common diagnosis in patients with AB/D. Symptoms were especially hard to be improved. Classification diagnoses of FGIDs in AB/D patients fluctuated significantly over time. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
Pharmacologic management of obesity: Updates on approved medications, indications and risks. AOMs have established efficacy and effectiveness for weight loss even beyond 52 weeks. Further pharmacological options, such as dual and triple incretins, are probable forthcoming additions to clinical practice for combating obesity and its metabolic consequences such as metabolic dysfunction-associated steatotic liver disease. |
Review article: Current status and future directions of ingestible electronic devices in gastroenterology. The development of miniaturised ingestible microelectronic-based devices offers exciting prospects for enhancing gastroenterological research and the delivery of personalised, point-of-care medicine. |
Review article: Diagnosis and management of laryngopharyngeal reflux. Patients with chronic laryngeal symptoms are complex due to the heterogenous nature of symptom pathology, inconsistent definitions and variable response to therapies. Further outcomes data are critically needed to help elucidate ideal diagnostic workup and therapeutic management for these challenging patients. |
| Endosc Int Open |
| J Hepatol |
| J Neurogastroenterol Motil |
Refractory Gastroesophageal Reflux Disease: Diagnosis and Management. Proper diagnosis and management of refractory GERD is critical to mitigate undesirable long-term complications such as strictures, Barrett's esophagus, and esophageal adenocarcinoma. This review outlines the diagnostic workup of patients presenting with refractory GERD symptoms, describes the distinction between unproven and proven GERD, and provides a comprehensive review of the current treatment strategies available for the management of refractory GERD. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Clin Gastroenterol Hepatol |
| Endosc Int Open |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Clin Gastroenterol Hepatol |
| Gut |
| J Hepatol |
| J Neurogastroenterol Motil |